CRISPR/Cas9-edited triple-fusion reporter gene imaging of dynamics and function of transplanted human urinary-induced pluripotent stem cell-derived cardiomyocytes.

Yuanxue GaoShuang WuJiayue PanKai ZhangXiaoyi LiYangyang XuChentao JinXiao HeJingjing ShiLijuan MaFujian WuYao YaoPing WangQinggang HeFeng LanHong ZhangMei Tian

Published in: European journal of nuclear medicine and molecular imaging (2020)

This study established a CRISPR/Cas9-mediated multimodality reporter gene imaging system that can determine the dynamics and function of TF-hUiCMs in myocardial infarction, which is helpful for investigating the application of stem cell therapy.

Keyphrases

crispr cas
genome editing
cell therapy
high resolution
high glucose
endothelial cells
copy number
genome wide
stem cells
mesenchymal stem cells
diabetic rats
oxidative stress
gene expression
bone marrow
mass spectrometry
fluorescence imaging
pluripotent stem cells
transcription factor