Towards an individualized management of pubertal induction in girls with hypogonadism: insight into the best replacement outcomes from a large multicentre registry.
Giulia RodariSilvia FedericiTommaso TodiscoGraziamaria UbertiniAlessandro CattoniMarta PaganoFederico GiacchettiEriselda ProfkaValeria CitterioDario MessettiValentina ColliniDavide SorannaErika CarboneArosio MauraMantovani GiovannaLuca PersaniMarco CappaMarco BonomiClaudia GiavoliPublished in: European journal of endocrinology (2023)
Our results provide evidence that progestins, hampering further changes in uterine volume and breast development, should be introduced only in the presence of a concomitant adequate 17β-oestradiol dose and an appropriate clinical response.