Ablation of secreted phosphoprotein-1 in hepatocytes increases fatty acid oxidation and ameliorates alcohol-associated liver disease.

Sukanta DasNithyananthan SubramaniyamRosa AlénSai Santosh Babu KomakulaZhuolun SongXiaodong GeHui HanRomain DesertDipti AthavaleFernando MagdalenoWei ChenInes BarahonaDaniel LantvitGrace GuzmanNatalia Nieto

Published in: Alcohol, clinical & experimental research (2024)

Alcohol induces the expression of SPP1 in hepatocytes, leading to impaired FAO and contributing to the development of AALD.

Keyphrases

fatty acid
poor prognosis
alcohol consumption
liver injury
hydrogen peroxide
mouse model
binding protein
long non coding rna