Dysregulation of lipid metabolism in the pseudolobule promotes region-specific autophagy in hepatitis B liver cirrhosis.
Wenjun PuXi WangXiaoni ZhongDong ZhaoZhipeng ZengWanxia CaiYafang ZhongJianrong HuangDonge TangYong DaiPublished in: Hepatology communications (2023)
Hepatitis B LC induced region-specific autophagy by increasing the expression of LC3B and p62 in the pseudolobule and by dysregulation of unsaturated fatty acids, amino acids, and PC metabolism. The mass spectrometry imaging system provided additional metabolites' spatial information, which can promote biomarker screening technology and support the exploration of novel mechanisms in LC.
Keyphrases
- mass spectrometry
- liquid chromatography
- fatty acid
- simultaneous determination
- cell death
- high resolution
- endoplasmic reticulum stress
- oxidative stress
- signaling pathway
- amino acid
- poor prognosis
- high performance liquid chromatography
- high glucose
- diabetic rats
- high resolution mass spectrometry
- ms ms
- solid phase extraction
- capillary electrophoresis
- gas chromatography
- binding protein
- healthcare
- health information
- endothelial cells
- drug induced
- photodynamic therapy