Increasing referral of at-risk women for genetic counseling and BRCA testing using a screening tool in a community breast imaging center.
Banu K ArunSusan K PetersonLilian E SweeneyRachel D BluebondRebecca S Slack TidwellSukh MakhnoonAnne C KushwahaPublished in: Cancer (2021)
Hereditary breast and ovarian cancer (HBOC) caused by pathogenic mutations in breast cancer genes (BRCA1/BRCA2) increase an individual's lifetime risk of getting HBOC. Identifying these high-risk individuals and using proven preventive clinical risk management strategies can significantly reduce their lifetime risk of HBOC. Using an innovative family cancer history questionnaire, 34,000 women were screened at a community breast imaging center, and genetic counseling and testing were provided to eligible women from the screening. Several women at high risk for HBOC were identified and this led to positive clinical risk management changes. These women would have been missed if not for intervention.
Keyphrases
- breast cancer risk
- polycystic ovary syndrome
- pregnancy outcomes
- cervical cancer screening
- healthcare
- high resolution
- mental health
- genome wide
- randomized controlled trial
- primary care
- insulin resistance
- gene expression
- copy number
- dna methylation
- squamous cell carcinoma
- cross sectional
- smoking cessation
- hepatitis c virus
- hiv infected
- human immunodeficiency virus
- hiv testing
- lymph node metastasis
- squamous cell