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Early versus Late initiation of direct oral Anticoagulants in post-ischaemic stroke patients with atrial fibrillatioN (ELAN): Protocol for an international, multicentre, randomised-controlled, two-arm, open, assessor-blinded trial.

Urs FischerSven TrelleMattia BrancaGeorgia SalantiMaurizio PaciaroniCecilia FerrariStefanie AbendSeraina BeyelerDaniel StrbianGötz ThomallaGeorge NtaiosLeo H BonatiPatrik MichelKrassen NedeltchevThomas GattringerElse Charlotte SandsetPeter J KellyRobin LemmensMasatoshi KogaPadmavathyamma Narayanapillai SylajaDiana Aguiar de SousaNatan M BornsteinZuzana GdovinováDavid Julian SeiffgeJan GrallaThomas HorvathJesse Dawson
Published in: European stroke journal (2022)
ELAN will estimate whether there is a clinically important difference in safety and efficacy outcomes following early anticoagulation with a DOAC compared to late guideline-based treatment in neuroimaging-selected people with an AIS due to AF.
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