Orthogonal genome editing and transcriptional activation in tomato using CRISPR-Combo systems.
Innocent ByiringiroChangtian PanYiping QiPublished in: Plant cell reports (2024)
The CRISPR-Combo systems (Cas9-Combo and CBE-Combo) are designed for comprehensive genetic manipulation, enabling Cas9-based targeted mutagenesis or cytosine base editing with simultaneous gene activation in tomato stable lines.