Acylcarnitines promote gallbladder cancer metastasis through lncBCL2L11-THOC5-JNK axis.
Yang YangHuaifeng LiKe LiuLu ZouShanshan XiangYajun GengXuechuan LiShimei QiuJiahua YangXuya CuiLin LiYang LiWeijian LiSiyuan YanLiguo LiuXiangsong WuFatao LiuWenguang WuShili ChenYing-Bin LiuPublished in: Journal of translational medicine (2024)
LncBCL2L11 is involved in gallbladder cancer metastasis through FAO metabolism. High lipid intake is associated with poor prognosis of GBC. Therefore, targeting lncBCL2L11 and its pathway-related proteins or reducing lipid intake may be significant for the treatment of GBC patients.
Keyphrases
- poor prognosis
- papillary thyroid
- long non coding rna
- end stage renal disease
- squamous cell
- ejection fraction
- newly diagnosed
- chronic kidney disease
- fatty acid
- signaling pathway
- prognostic factors
- cell death
- lymph node metastasis
- peritoneal dialysis
- weight gain
- cancer therapy
- body mass index
- patient reported outcomes
- physical activity
- young adults
- weight loss
- replacement therapy