Shikonin improves the effectiveness of PD-1 blockade in colorectal cancer by enhancing immunogenicity via Hsp70 upregulation.

Jinghua ChenJie LiuXiaolin LiuJun WangXiumei WangXin YeQi XieJing LiangYan Li

Published in: Molecular biology reports (2024)

Our study elucidated the potential role of 'Shikonin-PKM2-ROS-Hsp70' axis in the promotion of efficacy of PD-1 blockade in CRC treatments, providing a potential strategy and targets for improving the efficacy of PD-1 blockade in colorectal cancer.

Keyphrases

heat shock protein
heat shock
heat stress
randomized controlled trial
systematic review
cell death
cell proliferation
dna damage
human health
signaling pathway
poor prognosis