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Ensembl 2023.

Fergal J MartinM Ridwan AmodeAlisha AnejaOlanrewaju Austine-OrimoloyeAndrey G AzovIf BarnesArne BeckerRuth BennettAndrew BerryJyothish BhaiSimarpreet Kaur BhurjiAlexandra BignellSanjay BodduPaulo R Branco LinsLucy BrooksShashank Budhanuru RamarajuMehrnaz CharkhchiAlexander CockburnLuca Da Rin FiorrettoClaire DavidsonKamalkumar DodiyaSarah DonaldsonBilal El HoudaiguiTamara El NaboulsiReham FatimaCarlos Garcıa GironThiago GenezGurpreet S GhattaorayaJose Gonzalez MartinezCristi GuijarroMatthew HardyZoe HollisThibaut HourlierToby HuntMike KayVinay KaykalaTuan LeDiana LemosDiego Marques-CoelhoJosé Carlos MarugánGabriela Alejandra MerinoLouisse Paola MirabuenoAleena MushtaqSyed Nakib HossainDenye N OgehManoj Pandian SakthivelAnne ParkerMalcolm PerryIvana PiližotaIrina ProsovetskaiaJosé G Pérez-SilvaAhamed Imran Abdul SalamNuno Saraiva-AgostinhoHelen SchuilenburgDan SheppardSwati SinhaBotond SiposWilliam StarkEmily SteedRanjit SukumaranDulika SumathipalaMarie-Marthe SunerLikhitha SurapaneniKyösti SutinenMichal SzpakFrancesca Floriana TricomiDavid Urbina-GómezAndres VeidenbergThomas A WalshBrandon WaltsElizabeth WassNatalie WillhoftJamie AllenJorge Alvarez-JarretaMarc ChakiachviliBethany FlintStefano GiorgettiLeanne HaggertyGarth R IlsleyJane E LovelandBenjamin MooreJonathan M MudgeJohn TateDavid ThybertStephen J TrevanionAndrea WinterbottomAdam FrankishSarah E HuntMagali RuffierFiona CunninghamSarah DyerRobert D FinnKevin L HowePeter W HarrisonAndrew D YatesPaul Flicek
Published in: Nucleic acids research (2022)
Ensembl (https://www.ensembl.org) has produced high-quality genomic resources for vertebrates and model organisms for more than twenty years. During that time, our resources, services and tools have continually evolved in line with both the publicly available genome data and the downstream research and applications that utilise the Ensembl platform. In recent years we have witnessed a dramatic shift in the genomic landscape. There has been a large increase in the number of high-quality reference genomes through global biodiversity initiatives. In parallel, there have been major advances towards pangenome representations of higher species, where many alternative genome assemblies representing different breeds, cultivars, strains and haplotypes are now available. In order to support these efforts and accelerate downstream research, it is our goal at Ensembl to create high-quality annotations, tools and services for species across the tree of life. Here, we report our resources for popular reference genomes, the dramatic growth of our annotations (including haplotypes from the first human pangenome graphs), updates to the Ensembl Variant Effect Predictor (VEP), interactive protein structure predictions from AlphaFold DB, and the beta release of our new website.
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