Cell-type dependent regulation of pluripotency and chromatin remodeling genes by hydralazine.
Alain Aguirre-VázquezFabiola Castorena-TorresBeatriz Silva-RamírezKatia Peñuelas-UrquidesMaría Elena Camacho-MollLuis A Salazar-OlivoIván VelascoMario Bermudez de LeonPublished in: Stem cell research & therapy (2023)
Our data provide evidence that HYD regulates the expression of OCT4 and NANOG pluripotency genes as well as ARID1A and ARID2 genes, two members of the SWI/SNF chromatin remodeling complex family, in normal human dermal fibroblasts.
Keyphrases
- genome wide
- gene expression
- bioinformatics analysis
- genome wide identification
- dna methylation
- dna damage
- endothelial cells
- transcription factor
- poor prognosis
- embryonic stem cells
- electronic health record
- big data
- oxidative stress
- machine learning
- induced pluripotent stem cells
- pluripotent stem cells
- long non coding rna