Long noncoding RNA FER1L4 acts as an oncogenic driver in human pan-cancer.
Zilong YouAnqi GeDa PangYashuang ZhaoShouping XuPublished in: Journal of cellular physiology (2019)
The function of Fer-1 like family member 4 (FER1L4) in human pan-cancer is unknown. Expression of FER1L4 in tumor tissues and nontumor tissues, upstream regulation of FER1L4, and the relationship between its expression with prognosis and chemoresistance were examined by The Cancer Genome Atlas and Gene Expression Omnibus databases. Next, these results were validated in breast tumor and paired nontumor tissues in our cohort. FER1L4 expression is higher in tumor tissues compared with the adjacent nontumor tissues. High FER1L4 expression is associated with worse disease outcomes. Hypomethylation and H3K4me3 accumulation in FER1L4 promoter locus activate its transcriptional expression. Moreover, FER1L4 may trigger chemoresistance in human cancer. Gene Ontology enrichment analysis revealed that FER1L4 may be involved in processes associated with tumorigenesis. These results indicated that FER1L4 may act as an oncogenic driver and it may be a potential therapy target in human cancer.
Keyphrases
- gene expression
- papillary thyroid
- poor prognosis
- endothelial cells
- squamous cell
- long noncoding rna
- dna methylation
- transcription factor
- induced pluripotent stem cells
- lymph node metastasis
- pluripotent stem cells
- type diabetes
- young adults
- adipose tissue
- long non coding rna
- single cell
- genome wide
- oxidative stress
- childhood cancer
- squamous cell carcinoma
- metabolic syndrome
- weight loss
- climate change
- risk assessment
- human health
- machine learning
- big data