The Epigenetic Evolution of Glioma Is Determined by the IDH1 Mutation Status and Treatment Regimen.
Tathiane Maistro MaltaThais S SabedotNatalia S MorosiniIndrani DattaLuciano GarofanoWies R VallentgoedFrederick S VarnKenneth D AldapeFulvio D'AngeloSpyridon BakasJill S Barnholtz-SloanHui Kong GanMohammad HasanainAnn-Christin HauKevin C JohnsonSimona CazacuAna C deCarvalhoMustafa KhasrawEmre KocakavukMathilde C M KouwenhovenSimona MigliozziSimone P NiclouJohanna M NiersDavid Ryan OrmondSun Ha PaekGuido ReifenbergerPeter A E Sillevis SmittMarion SmitsLucy F SteadMartin J Van Den BentErwin G Van MeirAnnemiek M E WalenkampTobias WeissMichael WellerBart A WestermanBauke YlstraPieter WesselingAnna LasorellaPim J FrenchLaila M Poissonnull nullRoel G W VerhaakAntonio IavaroneHoutan NoushmehrPublished in: Cancer research (2024)
Standard treatments are related to loss of DNA methylation in IDHmut glioma, resulting in epigenetic activation of genes associated with tumor progression and alterations in the microenvironment that resemble treatment-naïve IDHwt glioma.