A dataset of proteomic changes during human heat stress and heat acclimation.
Daniel GagnonHadiatou BarryAmina BarhdadiEssaid OussaidIan MongrainLouis-Philippe Lemieux PerreaultMarie-Pierre DubéPublished in: Scientific data (2023)
Hotter climates have important impacts on human health and performance. Yet, the cellular and molecular responses involved in human heat stress and acclimation remain understudied. This dataset includes physiological measurements and the plasma concentration of 2,938 proteins collected from 10 healthy adults, before and during passive heat stress that was performed both prior to and after a 7-day heat acclimation protocol. Physiological measurements included body temperatures, sweat rate, cutaneous vascular conductance, blood pressure, and skin sympathetic nerve activity. The proteomic dataset was generated using the Olink Explore 3072 assay, enabling a high-multiplex antibody-based assessment of protein changes based on proximity extension assay technology. The data need to be interpreted in the context of the moderate level of body hyperthermia attained and the specific demographic of young, healthy adults. We have made this dataset publicly available to facilitate research into the cellular and molecular mechanisms involved in human heat stress and acclimation, crucial for addressing the health and performance challenges posed by rising temperatures.
Keyphrases
- heat stress
- heat shock
- endothelial cells
- human health
- blood pressure
- high throughput
- risk assessment
- induced pluripotent stem cells
- pluripotent stem cells
- randomized controlled trial
- healthcare
- mental health
- type diabetes
- big data
- machine learning
- metabolic syndrome
- high intensity
- insulin resistance
- single molecule
- heart rate
- hypertensive patients
- deep learning
- binding protein
- single cell
- soft tissue
- blood glucose
- middle aged