Structural implications of BK polyomavirus sequence variations in the major viral capsid protein Vp1 and large T-antigen: a computational study.
Janani DurairajOcéane M FollonierKaroline LeuzingerLeila T AlexanderMaud WilhelmJoana PereiraCaroline A HillenbrandFabian H WeissbachTorsten SchwedeHans H HirschPublished in: mSphere (2024)
Type and rate of amino acid variations in BKPyV may provide important insights into BKPyV diversity in human populations and an important step toward defining determinants of BKPyV-specific immunity needed to protect vulnerable patients from BKPyV diseases. Our analysis of BKPyV sequences obtained from human specimens reveals an unexpectedly high genetic variability for this double-stranded DNA virus that strongly relies on host cell DNA replication machinery with its proof reading and error correction mechanisms. BKPyV variability and immune escape should be taken into account when designing further approaches to antivirals, monoclonal antibodies, and vaccines for patients at risk of BKPyV diseases.
Keyphrases
- amino acid
- endothelial cells
- end stage renal disease
- newly diagnosed
- induced pluripotent stem cells
- chronic kidney disease
- sars cov
- peritoneal dialysis
- pluripotent stem cells
- single cell
- binding protein
- gene expression
- prognostic factors
- genome wide
- cell therapy
- mesenchymal stem cells
- small molecule
- patient reported outcomes
- nucleic acid
- genetic diversity