Global Regulator of Virulence A (GrvA) Coordinates Expression of Discrete Pathogenic Mechanisms in Enterohemorrhagic Escherichia coli through Interactions with GadW-GadE.
Jason K MorganRonan E O'CarrollCarly M HarroKhoury W VenduraLindsey N ShawJames T RiordanPublished in: Journal of bacteriology (2015)
Enterohemorrhagic Escherichia coli (EHEC) is an intestinal human pathogen causing acute hemorrhagic colitis and life-threatening hemolytic-uremic syndrome. For successful transmission and gut colonization, EHEC relies on the glutamate-dependent acid resistance (GDAR) system and a type III secretion apparatus, encoded on the LEE pathogenicity island. This study investigates the mechanism whereby the DNA-binding regulator GrvA coordinates activation of the LEE with repression of GDAR. Investigating how these systems are regulated leads to an understanding of pathogenic behavior and novel strategies aimed at disease prevention and control.
Keyphrases
- escherichia coli
- dna binding
- transcription factor
- type iii
- biofilm formation
- endothelial cells
- poor prognosis
- liver failure
- candida albicans
- staphylococcus aureus
- klebsiella pneumoniae
- respiratory failure
- drug induced
- induced pluripotent stem cells
- pluripotent stem cells
- antimicrobial resistance
- long non coding rna
- ulcerative colitis
- cystic fibrosis