Elevated plasma levels of cardiac troponin-I predict left ventricular systolic dysfunction in patients with myotonic dystrophy type 1: A multicentre cohort follow-up study.
Mark J HamiltonYvonne RobbSarah CummingHelen GregoryAlexis DuncanMonika RahmanAnne McKeownCatherine McWilliamJohn DeanAlison WilcoxMaria E FarrugiaAnneli CooperJosephine McGhieBerit AdamRichard Pettynull nullCheryl LongmanIain FindlayAlan JappDarren G MoncktonMartin A DenvirPublished in: PloS one (2017)
Plasma cTnI is highly elevated in some ambulatory patients with DM1 and shows promise as a tool to aid cardiac risk stratification, possibly by detecting myocardial involvement. Further studies with larger patient numbers are warranted to assess its utility in this setting.
Keyphrases
- left ventricular
- hypertrophic cardiomyopathy
- cardiac resynchronization therapy
- heart failure
- acute myocardial infarction
- blood pressure
- left atrial
- mitral valve
- aortic stenosis
- case report
- clinical trial
- oxidative stress
- study protocol
- early onset
- cross sectional
- randomized controlled trial
- case control
- muscular dystrophy
- insulin resistance
- skeletal muscle
- double blind
- coronary artery disease
- acute coronary syndrome
- glycemic control
- aortic valve
- deep learning
- artificial intelligence