A transposase-derived gene required for human brain development.

Luz Jubierre Zapater Elias Rodriguez-FosMerce Planas-FelixSara LewisDaniel CameronPhillip DemarestAnika NabilaJunfei ZhaoPaul BerginCasie ReedMakiko YamadaNicholas D SocciMatthew HayesRaúl RabadánDavid TorrentsMichael C KruerMiklos TothAlex Kentsis

Published in: bioRxiv : the preprint server for biology (2023)

PiggyBac Transposable Element Derived 5 (PGBD5) is required for brain development in humans and mice by promoting somatic neuronal genome rearrangements.

Keyphrases

genome wide
copy number
cerebral ischemia
white matter
skeletal muscle
adipose tissue
transcription factor
high fat diet induced
blood brain barrier
metabolic syndrome
brain injury
genome wide identification