Eicosatetraynoic Acid Regulates Pro-Fibrotic Pathways in an Induced Pluripotent Stem Cell Derived Macrophage:Human Intestinal Organoid Model of Crohn's Disease.

Ingrid JurickovaBenjamin W DreskinElizabeth AngermanErin BonkowskiJack NguyenRichard VillarrealKentaro TominagaKentaro IwasawaTzipi BraunTakanori TakebeMichael A HelmrathYael HabermanJames M WellsLee A Denson

Published in: Journal of Crohn's & colitis (2024)

ETYA inhibits pro-fibrotic effects of LPS-primed macrophages upon co-cultured HIO. This model may be used in future untargeted screens for small molecules to treat refractory CD.

Keyphrases

endothelial cells
anti inflammatory
high glucose
systemic sclerosis
idiopathic pulmonary fibrosis
high throughput
adipose tissue
current status
diabetic rats
gene expression
oxidative stress
drug induced
pluripotent stem cells