Translational impact of NIH-funded nonhuman primate research in transplantation.
Stuart J KnechtleJulia M ShawBernhard J HeringKristy KraemerJoren C MadsenPublished in: Science translational medicine (2020)
The National Institutes of Health (NIH) has long supported using nonhuman primate (NHP) models for research on kidney, pancreatic islet, heart, and lung transplantation. The primary purpose of this research has been to develop new treatments for down-modulating or preventing deleterious immune responses after transplantation in human patients. Here, we discuss NIH-funded NHP studies of immune cell depletion, costimulation blockade, regulatory cell therapy, desensitization, and mixed hematopoietic chimerism that either preceded clinical trials or prevented the human application of therapies that were toxic or ineffective.
Keyphrases
- cell therapy
- endothelial cells
- clinical trial
- immune response
- end stage renal disease
- induced pluripotent stem cells
- healthcare
- stem cells
- public health
- pluripotent stem cells
- chronic kidney disease
- mesenchymal stem cells
- newly diagnosed
- heart failure
- ejection fraction
- prognostic factors
- mental health
- signaling pathway
- transcription factor
- randomized controlled trial
- social media
- dendritic cells
- health information
- human health
- risk assessment
- open label
- case control