Circulating whole genome miRNA expression corresponds to progressive right ventricle enlargement and systolic dysfunction in adults with tetralogy of Fallot.
Chad S WeldySaad Ali SyedMyriam AmsallemDong-Qing HuXuhuai JiRajesh PunnAnne TaylorBrittany NavarreSushma ReddyPublished in: PloS one (2020)
Adults with TOF have a distinct miRNA profile with progressive RV enlargement and dysfunction implicating cell cycle dysregulation and upregulation in extracellular matrix and fatty acid metabolism. These data suggest peripheral blood miRNA can provide insight into the mechanisms of RV failure and can potentially be used for monitoring disease progression and to develop RV specific therapeutics to prevent RV failure in TOF.
Keyphrases
- mycobacterium tuberculosis
- cell cycle
- extracellular matrix
- peripheral blood
- cell proliferation
- poor prognosis
- mass spectrometry
- multiple sclerosis
- fatty acid
- ms ms
- oxidative stress
- heart failure
- blood pressure
- left ventricular
- pulmonary hypertension
- pulmonary artery
- small molecule
- mitral valve
- big data
- signaling pathway
- binding protein
- congenital heart disease
- machine learning
- artificial intelligence
- pulmonary arterial hypertension