Temporal and spatial progression of microstructural cerebral degeneration in ALS: A multicentre longitudinal diffusion tensor imaging study.
Hans-Peter MüllerAgessandro AbrahaoChristian BeaulieuMichael BenatarAnnie DionneAngela GengeRichard FrayneSimon J GrahamSummer GibsonLawrence KorngutCollin LukRobert C WelshLorne ZinmanJan KassubekSanjay KalraPublished in: NeuroImage. Clinical (2024)
Progressive microstructural alterations in ALS are most prominent in the CST and CC. DTI can provide a biomarker of cerebral degeneration in ALS, with longitudinal changes in white matter demonstrable over a reasonable observation period, with a feasible number of participants, and within a multicentre framework.