Login / Signup

XBP1-mediated transcriptional regulation of SLC5A1 in human epithelial cells in disease conditions.

Yifei SunYihan ZhangJifeng ZhangY Eugene ChenJian-Ping JinKezhong ZhangHongmei MouXiubin LiangJie Xu
Published in: Cell & bioscience (2024)
The present work establishes a causal relationship between ER stress and SGLT1 upregulation and provides a mechanistic explanation why SGLT inhibitor drugs benefit diseases beyond diabetes.
Keyphrases
  • endothelial cells
  • type diabetes
  • cardiovascular disease
  • poor prognosis
  • induced pluripotent stem cells
  • cell proliferation
  • pluripotent stem cells
  • signaling pathway
  • metabolic syndrome
  • insulin resistance