Regulation of human chorionic gonadotropin beta subunit expression in ovarian cancer.

Aleksandra ŚliwaMarta KubiczakAnna SzczerbaGrzegorz WalkowiakEwa Nowak-MarkwitzBeata BurczyńskaStephen ButlerRay IlesPiotr Białas Anna Jankowska

Published in: BMC cancer (2019)

In ovarian cancers increased expression of human chorionic gonadotropin beta subunit is associated with demethylation of CGB promoter regions. CGB3-9 expression level strongly correlates with expression of the TFAP2A transcription factor. Presence of mRNA arising from CGB1 and CGB2 genes appears to be a unique feature of a subset of ovarian cancers.

Keyphrases

poor prognosis
transcription factor
endothelial cells
binding protein
long non coding rna
dna methylation
machine learning
young adults
dna binding
pluripotent stem cells
protein kinase