RAPGEF2 mediates oligomeric Aβ-induced synaptic loss and cognitive dysfunction in the 3xTg-AD mouse model of Alzheimer's disease.

You-Na JangHoChung JangGyu Hyun KimJeong-Eun NohKeun-A ChangKea Joo Lee

Published in: Neuropathology and applied neurobiology (2021)

These findings demonstrate that the upregulation of RAPGEF2 levels mediates Aβ oligomer-induced synaptic and cognitive disturbances in the AD hippocampus. We propose that an early intervention regarding RAPGEF2 expression may have beneficial effects on early synaptic pathology and memory loss in AD.

Keyphrases

prefrontal cortex
poor prognosis
mouse model
high glucose
diabetic rats
randomized controlled trial
drug induced
cell proliferation
cognitive decline
signaling pathway
long non coding rna
working memory
cognitive impairment
binding protein
subarachnoid hemorrhage