Pulmonary Fibrosis Ferret Model Demonstrates Sustained Fibrosis, Restrictive Physiology, and Aberrant Repair.
Jacelyn E Peabody LeverQian LiNikoleta PavelkovaShah Saddad HussainSayan BakshiJanna Q RenLuke I JonesJared KennemurMason WeupeJavier Campos-GómezLiping TangJeremie M P LeverDezhi WangDenise D StanfordJeremy B FooteKevin S HarrodHarrison KimScott E PhillipsSteven M RowePublished in: bioRxiv : the preprint server for biology (2024)
Bleomycin-exposed ferrets exhibit sustained fibrosis through 22 wks and have pathologic features of IPF not found in rodents. Ferrets exhibited proximalization of the distal airways and other pathologic features characteristic of human IPF. MUC5B expression through native cell types may play a key role in promoting airway remodeling and lung injury in IPF.