Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids.
Amy R BentleyYun J SungMichael R BrownThomas W WinklerAldi T KrajaIoanna NtallaKaren SchwanderDaniel I ChasmanElise LimXuan DengXiuqing GuoJingmin LiuYingchang LuChing-Yu ChengXueling S SimDina VojinovicJennifer E HuffmanSolomon K MusaniChangwei LiMary F FeitosaMelissa A RichardRaymond NoordamJenna BakerGuanjie ChenHugues AschardTraci M BartzJingzhong DingRajkumar DorajooAlisa K ManningTuomo RankinenAlbert Vernon SmithSalman M TajuddinWei ZhaoMariaelisa GraffMaris AlverMathilde BoisselJin Fang ChaiXu ChenJasmin DiversEvangelos EvangelouChuan GaoAnuj GoelYanick Paco HagemeijerSarah E HarrisFernando Pires HartwigMeian HeAndrea R V R HorimotoFang-Chi HsuYi-Jen HungAnne U JacksonAnuradhani KasturiratnePirjo KomulainenBrigitte KühnelKarin LeanderKeng-Hung LinJian'an LuanLeo-Pekka LyytikainenNana MatobaIlja Maria NolteMaik PietznerBram PrinsMuhammad RiazAntonietta RobinoM Abdullah SaidNicole SchupfRobert A ScottTamar SoferAlena StancákováFumihiko TakeuchiBamidele O TayoPeter J van der MostTibor V VargaTzung-Dau WangYajuan WangErin B WareWanqing WenYong-Bing XiangLisa R YanekWeihua ZhangJing Hua ZhaoAdebowale A AdeyemoSaima AfaqNajaf AminMarzyeh AminiDan E ArkingZorayr ArzumanyanTin AungChristie BallantyneR Graham BarrLawrence F BielakEric BoerwinkleErwin P BottingerUlrich BroeckelMorris BrownBrian E CadeArchie I CampbellMickaël CanouilSabanayagam CharumathiYii-Der Ida ChenKaare Christensennull nullMaria Pina ConcasJohn M ConnellLisa de Las FuentesH Janaka de SilvaPaul S de VriesAyo DoumateyQing DuanCharles B EatonRuben N EppingaJessica D FaulJames S FloydNita G ForouhiTerrence ForresterYechiel FriedlanderIlaria GandinHe GaoMohsen GhanbariSina A GharibBruna GiganteFranco GiulianiniHans J GrabeC Charles GuTamara B HarrisSami HeikkinenChew-Kiat HengMakoto HirataJames E HixsonMohammad Arfan Ikramnull nullYucheng JiaRoby JoehanesCraig JohnsonJost Bruno JonasAnne E JusticeTomohiro KatsuyaChiea Chuen KhorTuomas O KilpeläinenWoon-Puay KohIvana KolcicCharles KooperbergJose Eduardo KriegerStephen B KritchevskyMichiaki KuboJohanna KuusistoTimo A LakkaCarl D LangefeldClaudia LangenbergLenore J LaunerBenjamin LehneCora E LewisYize LiJingjing LiangShiow LinChing-Ti LiuJian-Jun LiuKiang LiuMarie LohKurt K LohmanTin LouieAnna LuzziReedik MägiAnubha MahajanAni W ManichaikulColin A McKenzieThomas MeitingerAndres MetspaluYuri MilaneschiLili A MilaniKaren L MohlkeYukihide MomozawaAndrew P MorrisAlison D MurrayMike A NallsMatthias NauckChristopher P NelsonKari E NorthJeffrey R O'ConnellNicholette D PalmerGeorge J PapanicolauNancy L PedersenAnnette PetersPatricia A PeyserOzren PolasekNeil PoulterOlli T RaitakariAlex P ReinerFrida RenströmTreva K RiceStephen S RichJennifer G RobinsonLynda M RoseFrits R RosendaalIgor RudanCarsten O SchmidtPamela J SchreinerWilliam R ScottPeter SeverYuan ShiStephen SidneyMario SimsJennifer A SmithHarold SniederJohn M StarrKonstantin StrauchHeather M StringhamNicholas Y Q TanHua TangKent D TaylorYik Ying TeoYih Chung ThamHenning TiemeierStephen T TurnerAndré G Uitterlindennull nullDiana van HeemstMelanie WaldenbergerHeming WangLan WangLihua WangWen Bin WeiChristine A WilliamsGregory WilsonMary K WojczynskiJie YaoKristin L YoungCaizheng YuWoon-Puay KohJie ZhouAlan B ZondermanDiane M BeckerMichael BoehnkeDonald W BowdenJohn C ChambersRichard S CooperUlf de FaireIan J DearyPaul ElliottTõnu EskoMartin FarrallPaul W FranksBarry I FreedmanPhillippe FroguelPaolo GaspariniChristian GiegerBernardo Lessa HortaJyh-Ming Jimmy JuangYoichiro KamataniCandace M KammererNorihiro KatoJaspal S KoonerMarkku LaaksoCathy C LaurieI-Te LeeTerho Lehtimäkinull nullPatrik K E MagnussonAlbertine J OldehinkelBrenda W J H PenninxAlexandre C PereiraRainer RauramaaSusan RedlineNilesh J SamaniJames ScottXiao-Ou ShuPim van der HarstLynne E WagenknechtJun-Sing WangYa-Xing WangNicholas J WarehamHugh WatkinsDavid R WeirAnanda R WickremasingheTangchun WuEleftheria ZegginiQuan LongClaude BouchardMichele K EvansVilmundur G GudnasonSharon L R KardiaYongmei LiuBruce M PsatyPaul M RidkerRob M van DamDennis O Mook-KanamoriMyriam FornageMichael A ProvinceTanika N KellyErvin R FoxCaroline HaywardCornelia M van DuijnE Shyong TaiTien Yin WongRuth J F LoosNora FranceschiniJerome I RotterXiaofeng ZhuLaura J BierutW James GaudermanKenneth M RicePatricia B MunroeAlanna C MorrisonDabeeru C RaoCharles N RotimiL Adrienne CupplesPublished in: Nature genetics (2019)
The concentrations of high- and low-density-lipoprotein cholesterol and triglycerides are influenced by smoking, but it is unknown whether genetic associations with lipids may be modified by smoking. We conducted a multi-ancestry genome-wide gene-smoking interaction study in 133,805 individuals with follow-up in an additional 253,467 individuals. Combined meta-analyses identified 13 new loci associated with lipids, some of which were detected only because association differed by smoking status. Additionally, we demonstrate the importance of including diverse populations, particularly in studies of interactions with lifestyle factors, where genomic and lifestyle differences by ancestry may contribute to novel findings.