Login / Signup

Palladium/Norbornene Cooperative Catalysis Bifunctionalization: Acylation/Cyanation of Aryl Iodides by Cleaving C-CN Bond of Aryl Acyl Nitrile.

Hang LiuYi-Xin ChaiJun-Jie YangDan MiaoMeng-Yao WangTing JiangYuan-Yuan SunXin LuQing SunJin-Heng LiYan-Ping Zhu
Published in: Organic letters (2024)
A palladium/norbornene catalyzed two-component coupling process involving acylation/cyanation of aryl iodides is reported. In this work, aryl acyl nitrile compounds are cleverly selected to provide both nitrile and acyl sources by palladium-catalyzed cleavage of the C-CN bond as both an electrophilic reagent and a termination reagent. This is the first example of C-CN bond cleavage bifunctionalization of aryl iodides. After a series of important NBE derivatives are screened, the products resulting from the bifunctionalization of aryl iodides are smoothly obtained. This strategy has a wide range of substrates and good functional group compatibility. Moreover, this synthetic protocol demonstrated a good application for the synthesis of diverse O , N , C -substituted isoindolinones.
Keyphrases
  • lymph node metastasis
  • fatty acid
  • randomized controlled trial
  • room temperature
  • gold nanoparticles
  • molecular docking