Contamination and oxidative stress biomarkers in estuarine fish following a mine tailing disaster.
Fabrício  GabrielRachel Ann Hauser DavisLorena SoaresAna Carolina A MazzucoRafael Christian Chavez RochaTatiana D Saint PierreEnrico SaggioroFabio Verissimo CorreiaTiago Osório FerreiraAngelo Fraga BernardinoPublished in: PeerJ (2020)
Our results revealed high trace metal concentrations in estuarine sediments, when compared to published baseline values for the same estuary. The demersal fish species C. spixii and G. genidens had the highest concentrations of As, Cr, Mn, Hg, and Se in both, hepatic and muscle, tissues. Trace metal bioaccumulation in fish was correlated with the biosynthesis of metallothionein and reduced glutathione in both, liver and muscle, tissues, suggesting active physiological responses to contamination sources. The trace metal concentrations determined in fish tissues were also present in the estuarine sediments at the time of this study. Some elements had concentrations above the maximum permissible limits for human consumption in fish muscles (e.g., As, Cr, Mn, Se and Zn), suggesting potential human health risks that require further studies. Our study supports the high biogeochemical mobility of toxic elements between sediments and the bottom-dwelling biota in estuarine ecosystems.
Keyphrases
- heavy metals
- risk assessment
- health risk
- oxidative stress
- endothelial cells
- drinking water
- health risk assessment
- gene expression
- human health
- skeletal muscle
- dna damage
- induced pluripotent stem cells
- signaling pathway
- room temperature
- randomized controlled trial
- fluorescent probe
- pluripotent stem cells
- ischemia reperfusion injury
- single cell
- heat shock protein