Delving into Early-onset Pancreatic Ductal Adenocarcinoma: How Does Age Fit In?

Erica S TsangJames T TophamJoanna M KarasinskaMichael Kuan-Ching LeeLaura M WilliamsonShehara Mendis Robert E DenrocheGun Ho JangSteve E KallogerRichard A MooreAndrew J Mungall Oliver F Bathe Patricia A TangFaiyaz NottaJulie M WilsonJanessa LaskinGrainne M O'KaneJennifer J KnoxRachel A GoodwinJonathan M Loree Steven J M Jones Marco A MarraSteven GallingerDavid F SchaefferDaniel J Renouf

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2020)

Our comprehensive analysis of sequencing data generated from a large cohort of PDAC patient samples highlights a distinctive pattern of biallelic CDKN2A mutation in EOPC tumors. Increased expression of FOXC2 in EOPC, with the correlation between FOXC2 and EMT pathways, represents novel molecular characteristics of EOPC.See related commentary by Lou, p. 8.

Keyphrases

early onset
late onset
poor prognosis
epithelial mesenchymal transition
case report
electronic health record
intellectual disability
single cell
big data
single molecule
long non coding rna
autism spectrum disorder
drug induced
signaling pathway