Metabolomic signatures after bariatric surgery - a systematic review.
Matilde VazSofia S PereiraMariana P MonteiroPublished in: Reviews in endocrine & metabolic disorders (2021)
Metabolomics emerged as an important tool to gain insights on how the body responds to therapeutic interventions. Bariatric surgery is the most effective treatment for severe obesity and obesity-related co-morbidities. Our aim was to conduct a systematic review of the available data on metabolomics profiles that characterize patients submitted to different bariatric surgery procedures, which could be useful to predict clinical outcomes including weight loss and type 2 diabetes remission. For that, the Preferred Reporting Items for Systematic Reviews and Meta-Analyses - PRISMA guidelines were followed. Data from forty-seven original study reports addressing metabolomics profiles induced by bariatric surgery that met eligibility criteria were compiled and summarized. Amino acids, lipids, energy-related and gut microbiota-related were the metabolite classes most influenced by bariatric surgery. Among these, higher pre-operative levels of specific lipids including phospholipids, long-chain fatty acids and bile acids were associated with post-operative T2D remission. As conclusion, metabolite profiling could become a useful tool to predict long term response to different bariatric surgery procedures, allowing more personalized interventions and improved healthcare resources allocation.
Keyphrases
- bariatric surgery
- weight loss
- obese patients
- meta analyses
- roux en y gastric bypass
- type diabetes
- gastric bypass
- fatty acid
- healthcare
- mass spectrometry
- systematic review
- glycemic control
- end stage renal disease
- electronic health record
- metabolic syndrome
- insulin resistance
- chronic kidney disease
- amino acid
- ejection fraction
- adverse drug
- cardiovascular disease
- gene expression
- drug induced
- randomized controlled trial
- physical activity
- machine learning
- tyrosine kinase
- peritoneal dialysis
- clinical practice
- skeletal muscle
- prognostic factors
- patient reported outcomes
- body mass index
- single cell
- adipose tissue
- patient reported