Flavonoids as emerging notch signaling pathway modulators in cancer.
Atul Kumar SinghSabyasachi SenapatiPublished in: Journal of Asian natural products research (2023)
Notch signaling is an evolutionary conserved pathway important for the developmental processes and implicated in the tumor formation. Notch signaling pathway (NSP) inhibitors have been tested in clinical trials alone or in combination with the chemotherapy but none got clinical approval due to severe toxicity in patients. Flavonoids inhibit NSP by inhibiting notch receptor cleavage and/or inhibiting transcriptional regulation by Notch intracellular domain (NICD). Interestingly, some flavonoids are reported to inhibit NSP by mediating the microRNA expression. NSP inhibitory flavonoid(s) in combination with standard therapy is might be an effective strategy in cancer treatment.
Keyphrases
- signaling pathway
- cell proliferation
- pi k akt
- clinical trial
- induced apoptosis
- end stage renal disease
- epithelial mesenchymal transition
- poor prognosis
- newly diagnosed
- small molecule
- transcription factor
- oxidative stress
- papillary thyroid
- binding protein
- genome wide
- squamous cell carcinoma
- gene expression
- peritoneal dialysis
- randomized controlled trial
- dna binding
- endoplasmic reticulum stress
- cell therapy
- dna methylation
- reactive oxygen species
- smoking cessation
- bone marrow
- replacement therapy
- study protocol
- phase iii
- oxide nanoparticles