Signs of Glucagon Resistance After a Two-Week Hypercaloric Diet Intervention.
Malte Palm SuppliAstrid HøgedalJonatan Ising BaggerElizaveta ChabanovaGerrit van HallJulie Lyng FormanMikkel Bring ChristensenNicolai Jacob Wewer AlbrechtsenJens Juul HolstFilip K Krag KnopPublished in: The Journal of clinical endocrinology and metabolism (2023)
Our results indicate that short-term unhealthy behavior, which increases hepatic fat content, causes a reversible resistance to the effect of glucagon on amino acid concentrations in healthy individuals, which may explain the hyperglucagonemia associated with obesity and diabetes.