Trackable Intratumor Microdosing and Spatial Profiling Provide Early Insights into Activity of Investigational Agents in the Intact Tumor Microenvironment.
Jonathan M J DerryConnor BurnsJason P FrazierEmily BeirneMarc GrenleyChristopher C DuFortEmily E KillingbeckMichael LeonClaire R WilliamsMark T GregoryJeffrey J HoultonDaniel R ClayburghPaul L SwiecickiDennis HuszarAllison J BergerRichard A KlinghofferPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2023)
Pairing CIVO with spatial profiling enabled detailed investigation of response to subasumstat across a diverse sampling of native and intact TMEs. We demonstrate that drug mechanism of action can be directly evaluated in a spatially precise manner in the most translationally relevant setting: an in situ human tumor.