Novel Peptides from Sea Cucumber Intestinal Enzyme Hydrolysates Promote Osteogenic Differentiation of Bone Mesenchymal Stem Cells via Phosphorylation of PPARγ at Serine 112.
Hao YueZhibing LengYuying BoYingying TianZiyi YanChanghu XuePing DongJingfeng WangPublished in: Molecular nutrition & food research (2023)
Supplement with SCIP promotes BMSCs to differentiate into osteoblasts. These results suggest that SCIP has potential as a functional food to improve obesity and osteoporosis.
Keyphrases
- bone mineral density
- mesenchymal stem cells
- insulin resistance
- protein kinase
- postmenopausal women
- human health
- metabolic syndrome
- umbilical cord
- weight loss
- high fat diet induced
- type diabetes
- body composition
- weight gain
- adipose tissue
- bone marrow
- risk assessment
- skeletal muscle
- cell therapy
- soft tissue
- bone loss
- amino acid
- bone regeneration
- climate change
- fatty acid
- physical activity
- body mass index