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Lipophagy and Lipolysis Status in Lipid Storage and Lipid Metabolism Diseases.

Anna KloskaMagdalena WęsierskaMarcelina MalinowskaMagdalena Gabig-CimińskaJoanna Jakóbkiewicz-Banecka
Published in: International journal of molecular sciences (2020)
This review discusses how lipophagy and cytosolic lipolysis degrade cellular lipids, as well as how these pathway ys communicate, how they affect lipid metabolism and energy homeostasis in cells and how their dysfunction affects the pathogenesis of lipid storage and lipid metabolism diseases. Answers to these questions will likely uncover novel strategies for the treatment of aforementioned human diseases, but, above all, will avoid destructive effects of high concentrations of lipids-referred to as lipotoxicity-resulting in cellular dysfunction and cell death.
Keyphrases
  • fatty acid
  • cell death
  • cell cycle arrest
  • adipose tissue
  • induced apoptosis
  • oxidative stress
  • endothelial cells
  • cell proliferation
  • induced pluripotent stem cells
  • pluripotent stem cells