Decitabine increases neoantigen and cancer testis antigen expression to enhance T-cell-mediated toxicity against glioblastoma.
Ruichong MaMargarida ReiIsaac WoodhouseKatherine FerrisSophie KirschnerAnandhakumar ChandranUzi GileadiJi-Li ChenMariana Pereira PinhoYoanna Ariosa-MorejonSkirmantas KriaucionisNicola TernetteHashem KoohyOlaf AnsorgeGraham OggPuneet PlahaVincenzo CerundoloPublished in: Neuro-oncology (2022)
Our work shows that DAC increases GBM immunogenicity and consequent susceptibility to T-cell responses in vitro. Our results support a potential use of DAC as a sensitizing agent for immunotherapy.