An efficient in vivo -inducible CRISPR interference system for group A Streptococcus genetic analysis and pathogenesis studies.
Elisabet BjanesAlexandra StreamAxel B JanssenPaddy S GibsonAfonso M BravoSamira DaheshJonathon L BakerAndrew VarbleVictor NizetJan-Willem van GroenigenPublished in: mBio (2024)
in a mouse infection model. Additionally, we present SpyBrowse, an intuitive and accessible genome browser (https://veeninglab.com/SpyBrowse). Overall, this work overcomes significant technical challenges of working with GAS and, together with SpyBrowse, represents a valuable resource for researchers in the GAS field.