Gene Expression and Protein Abundance of Nuclear Receptors in Human Intestine and Liver: A New Application for Mass Spectrometry-Based Targeted Proteomics.
Christoph WenzelLisa GödtkeAnne ReichsteinMarkus KeiserDiana BuschMarek DroździkStefan OswaldPublished in: Molecules (Basel, Switzerland) (2022)
The substantially different expression pattern of nuclear receptors in human intestinal and liver tissue may explain the different extent of unwanted DDIs in the dependence on the administration route of drugs.
Keyphrases
- mass spectrometry
- gene expression
- endothelial cells
- dna methylation
- poor prognosis
- pluripotent stem cells
- high resolution
- high performance liquid chromatography
- small molecule
- gas chromatography
- capillary electrophoresis
- antibiotic resistance genes
- long non coding rna
- microbial community
- simultaneous determination
- tandem mass spectrometry
- solid phase extraction