Expression and function of mechanosensitive ion channels in human valve interstitial cells.
Hessah Al-ShammariNajma LatifPadmini SarathchandraAnn McCormackEva A Rog-ZielinskaShahzad RajaPeter KohlMagdi H YacoubRémi PeyronnetAdrian H ChesterPublished in: PloS one (2020)
Aortic VIC express a range of MSC that play a role in functional responses of these cells to mechanical stimulation. MSC expression levels differ in calcified and non-calcified valves in ways that are in part compatible with the change in expression seen between VIC phenotypes. These changes in MSC expression, and associated alterations in the ability of VIC to respond to their mechanical environment, may form novel targets for intervention during aortic valvulopathies.
Keyphrases
- poor prognosis
- aortic valve
- induced apoptosis
- randomized controlled trial
- binding protein
- endothelial cells
- cell cycle arrest
- left ventricular
- heart failure
- long non coding rna
- oxidative stress
- endoplasmic reticulum stress
- pulmonary artery
- mitral valve
- signaling pathway
- cell death
- transcatheter aortic valve replacement
- aortic valve replacement
- aortic stenosis