Chitooligosaccharide prevents vascular endothelial cell apoptosis by attenuation of endoplasmic reticulum stress via suppression of oxidative stress through Nrf2-SOD1 up-regulation.

Zin Zin EiPilaiwanwadee HutamekalinPeerada PrommeenateAvtar Singh Soottawat BenjakulKittichate VisuttijaiPithi Chanvorachote

Published in: Pharmaceutical biology (2022)

COS protected against ER stress-induced apoptosis in endothelial cells by suppressing ROS and up-regulation Nrf2 and SOD1. These findings support the use of COS to protect endothelial cells.

Keyphrases

induced apoptosis
oxidative stress
endothelial cells
endoplasmic reticulum stress
dna damage
high glucose
diabetic rats
ischemia reperfusion injury
amyotrophic lateral sclerosis
signaling pathway
vascular endothelial growth factor
cell death
cell proliferation
reactive oxygen species
heat shock protein