Enhanced Th1 and inflammatory mRNA responses upregulate NK cell cytotoxicity and NKG2D ligand expression in human pre-eclamptic placenta and target it for NK cell attack.
Marie-Therese VinnarsEmma BjörkIvan NagaevUlrika OttanderKatarina BremmeUlrika HolmlundEva Sverremark-EkströmLucia Mincheva-NilssonPublished in: American journal of reproductive immunology (New York, N.Y. : 1989) (2018)
The destruction of chorionic villi observed in PE placenta might be conveyed by an enhanced local cytotoxic response through the NKG2D receptor-ligand pathway, which in turn might be promoted by an intense inflammatory response not counteracted by regulatory cytokine responses.