Efficacy and safety of intravenous ketamine treatment in Japanese patients with treatment-resistant depression: A double-blind, randomized, placebo-controlled trial.

Yohei OhtaniHideaki TaniKie Nomoto-TakahashiTaisuke YatomiKengo YonezawaSota TomiyamaNobuhiro NagaiKeisuke KusudoShiori HondaSotaro MoriyamaShinichiro NakajimaTakashige YamadaHiroshi MorisakiYu IwabuchiMasahiro JinzakiKimio YoshimuraTsuyoshi EiroSakiko TsugawaSadamitsu IchijoYu FujimotoTomoyuki MiyazakiTakuya TakahashiHiroyuki Uchida

Published in: Psychiatry and clinical neurosciences (2024)

Intravenous ketamine outperformed placebo in Japanese patients with TRD who completed the study, suggesting that ketamine could alleviate depressive symptoms of TRD across diverse ethnic populations.

Keyphrases

double blind
depressive symptoms
pain management
placebo controlled
high dose
phase iii
clinical trial
open label
sleep quality
social support
phase ii
randomized controlled trial
replacement therapy