[The role of glial cell line-derived neurotrophic factor isoforms in human glial tumors].
A V RevishchinV V ParshinaGalina Valerievna PavlovaPublished in: Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko (2022)
Glial cell line-derived neurotrophic factor (GDNF) has a wide range of actions and positively affects viability, proliferative activity and migratory ability of cells in nervous system. That is why GDNF is being considered as a therapeutic molecule in the treatment of neurodegenerative diseases, in particular Parkinson's disease. However, GDNF has the same effect on high-grade glioma cells promoting their growth, resistance to therapy and dissemination. Expression of this factor in tissues and cultures of gliomas is up to five times higher than in intact brain matter. It was revealed that epigenetic modifications in GDNF gene promoter contribute to overexpression. Target suppression of GDNF gene transcription slows down growth of glioma and decreases cell migration. This review is devoted to the effect of GDNF on glioma cells, causes and consequences of its overexpression. Further analysis of expression and function of various GDNF isoforms in glial tumors may be valuable to develop new treatment methods for these dangerous diseases.
Keyphrases
- high grade
- cell migration
- poor prognosis
- transcription factor
- neuropathic pain
- gene expression
- dna methylation
- genome wide
- induced apoptosis
- cell proliferation
- copy number
- endothelial cells
- single cell
- multiple sclerosis
- spinal cord
- long non coding rna
- mesenchymal stem cells
- endoplasmic reticulum stress
- pluripotent stem cells
- brain injury
- subarachnoid hemorrhage
- cerebral ischemia