Selenium Nanoparticles by Moderating Oxidative Stress Promote Differentiation of Mesenchymal Stem Cells to Osteoblasts.
Sabiha FatimaRawan AlfrayhMay AlrashedSarah AlsobaieRehan AhmadAmer MahmoudPublished in: International journal of nanomedicine (2021)
The results approved that low concentrations of SeNPs might enhance the cell viability and osteogenic potential of hMSCs by moderating OS. Increased JNK and FOXO3a expression shows that SeNPs might enhance osteogenesis via activation of the JNK/FOXO3 pathway. In addition, SeNP co-supplementation might prevent bone loss by enhancing osteogenesis and, thus, can be an effective candidate for treating osteoporosis through cell-based therapy.
Keyphrases
- mesenchymal stem cells
- signaling pathway
- bone loss
- induced apoptosis
- cell therapy
- oxidative stress
- pi k akt
- umbilical cord
- social support
- transcription factor
- bone marrow
- poor prognosis
- cell death
- single cell
- postmenopausal women
- dna damage
- endoplasmic reticulum stress
- bone regeneration
- binding protein
- ischemia reperfusion injury
- stem cells
- depressive symptoms
- long non coding rna
- heat stress
- replacement therapy
- climate change
- oxide nanoparticles