No Differences in Cerebral Immunohistochemical Markers following Remote Ischemic Postconditioning in Newborn Piglets with Hypoxia-Ischemia.
Hannah B AndersenMads AndersenKristine BennedsgaardSigrid Kerrn-JespersenKasper J KyngIda E HolmTine B HenriksenPublished in: Neuropediatrics (2022)
RIPC did not influence brain expression of markers related to edema, apoptosis, or angiogenesis in newborn piglets at 72 hours after HI. These results support previous findings of limited neuroprotective effect by this RIPC protocol. Our results may have been affected by the time of assessment, use of fentanyl as anesthetic, or limitations related to our immunohistochemical methods.
Keyphrases
- cerebral ischemia
- subarachnoid hemorrhage
- endothelial cells
- ischemia reperfusion injury
- poor prognosis
- oxidative stress
- randomized controlled trial
- blood brain barrier
- brain injury
- cell death
- endoplasmic reticulum stress
- white matter
- vascular endothelial growth factor
- cell cycle arrest
- resting state
- binding protein
- drug induced
- clinical evaluation