CSF neurofilament light chain testing as an aid to determine treatment strategies in MS.
Saúl ReyesIde SmetsDavid HoldenKarina Carrillo-LozaTatiana ChristmasLucia BianchiFrancesca AmmoscatoBenjamin TurnerMonica MartaKlaus SchmiererGavin GiovannoniSharmilee GnanapavanPublished in: Neurology(R) neuroimmunology & neuroinflammation (2020)
CSF NfL measurements informed treatment strategies, alongside clinical and MRI measures. CSF NfL levels were the only indicator of disease activity in a subset of patients, which was more pronounced in patients with PMS. Elevated CSF NfL was associated with more Treatment/Escalation strategies, which had an impact on EDSS outcomes at 1 year.
Keyphrases
- disease activity
- cerebrospinal fluid
- rheumatoid arthritis
- systemic lupus erythematosus
- end stage renal disease
- newly diagnosed
- ejection fraction
- rheumatoid arthritis patients
- magnetic resonance imaging
- ankylosing spondylitis
- chronic kidney disease
- mass spectrometry
- multiple sclerosis
- ms ms
- peritoneal dialysis
- juvenile idiopathic arthritis
- magnetic resonance
- randomized controlled trial
- adipose tissue
- computed tomography
- open label
- smoking cessation