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Neovascular Prostate-Specific Membrane Antigen Expression Is Associated with Improved Overall Survival under Palliative Chemotherapy in Patients with Pancreatic Ductal Adenocarcinoma.

Katharina StockKonrad SteinestelRebekka WieschJan-Henrik MikeschAnna HansmeierMarcel TrautmannNora BellerJan RehkämperEva WardelmannBirthe HeitkötterWolfgang HartmannJan SperveslageSebastian Huss
Published in: BioMed research international (2017)
PSMA expression in tumor-associated neovasculature is a common feature and associated with improved overall survival under palliative chemotherapy in PDAC. Our results point towards a possible association between PSMA expression and response to therapy which might be based on enhanced intratumoral bioavailability of systemic chemotherapy.
Keyphrases
  • poor prognosis
  • prostate cancer
  • locally advanced
  • palliative care
  • binding protein
  • machine learning
  • deep learning
  • advanced cancer
  • vascular endothelial growth factor
  • bone marrow
  • smoking cessation
  • replacement therapy