Neovascular Prostate-Specific Membrane Antigen Expression Is Associated with Improved Overall Survival under Palliative Chemotherapy in Patients with Pancreatic Ductal Adenocarcinoma.

Katharina StockKonrad SteinestelRebekka WieschJan-Henrik MikeschAnna HansmeierMarcel TrautmannNora BellerJan RehkämperEva WardelmannBirthe HeitkötterWolfgang HartmannJan SperveslageSebastian Huss

Published in: BioMed research international (2017)

PSMA expression in tumor-associated neovasculature is a common feature and associated with improved overall survival under palliative chemotherapy in PDAC. Our results point towards a possible association between PSMA expression and response to therapy which might be based on enhanced intratumoral bioavailability of systemic chemotherapy.

Keyphrases

poor prognosis
prostate cancer
locally advanced
palliative care
binding protein
machine learning
deep learning
advanced cancer
vascular endothelial growth factor
bone marrow
smoking cessation
replacement therapy