Neovascular Prostate-Specific Membrane Antigen Expression Is Associated with Improved Overall Survival under Palliative Chemotherapy in Patients with Pancreatic Ductal Adenocarcinoma.
Katharina StockKonrad SteinestelRebekka WieschJan-Henrik MikeschAnna HansmeierMarcel TrautmannNora BellerJan RehkämperEva WardelmannBirthe HeitkötterWolfgang HartmannJan SperveslageSebastian HussPublished in: BioMed research international (2017)
PSMA expression in tumor-associated neovasculature is a common feature and associated with improved overall survival under palliative chemotherapy in PDAC. Our results point towards a possible association between PSMA expression and response to therapy which might be based on enhanced intratumoral bioavailability of systemic chemotherapy.