Key signaling networks are dysregulated in patients with the adipose tissue disorder, lipedema.
Musarat IshaqNadeeka BandaraSteven MorganCameron J NowellAhmad M MehdiRuqian LyuDavis J McCarthyDovile AndersonDarren J CreekMarc G AchenRamin ShayanTara KarnezisPublished in: International journal of obesity (2005) (2021)
We found significant differences in gene expression, and lipid and metabolite profiles, in tissue, ADSCs, and adipocytes from lipedema patients compared to non-affected controls. Functional assays demonstrated that dysregulated Bub1 signaling drives increased proliferation of lipedema ADSCs, suggesting a potential mechanism for enhanced adipogenesis in lipedema. Importantly, our characterization of signaling networks driving lipedema identifies potential molecular targets, including Bub1, for novel lipedema therapeutics.
Keyphrases
- adipose tissue
- gene expression
- end stage renal disease
- ejection fraction
- newly diagnosed
- dna methylation
- insulin resistance
- small molecule
- signaling pathway
- peritoneal dialysis
- genome wide
- human health
- metabolic syndrome
- risk assessment
- fatty acid
- patient reported outcomes
- climate change
- high fat diet induced
- single molecule
- single cell