Fish Oil Derived Omega 3 Fatty Acids Suppress Adipose NLRP3 Inflammasome Signaling in Human Obesity.
Kailey Roberts LeeYasmeen MidgetteRachana ShahPublished in: Journal of the Endocrine Society (2018)
N-3 PUFA reduce NLRP3 inflammasome in human adipose through downregulation of gene expression in adipocytes and monocytes/macrophages and has potential as nutritional therapeutic agent in prevention of obesity-related inflammation.
Keyphrases
- nlrp inflammasome
- insulin resistance
- gene expression
- endothelial cells
- adipose tissue
- fatty acid
- metabolic syndrome
- high fat diet induced
- type diabetes
- weight loss
- induced pluripotent stem cells
- oxidative stress
- weight gain
- pluripotent stem cells
- dna methylation
- skeletal muscle
- signaling pathway
- body mass index
- dendritic cells
- physical activity
- risk assessment